A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis in a contaminated in vivo bone defect model.

@article{McLaren2014ABA,
  title={A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis in a contaminated in vivo bone defect model.},
  author={Jane S. McLaren and Lisa J. White and Helen C. Cox and Warda Ashraf and Cheryl V. Rahman and G. Blunn and Allen E Goodship and Robin A. Quirk and Kevin M. Shakesheff and Roger R Bayston and Brigitte E Scammell},
  journal={European cells & materials},
  year={2014},
  volume={27},
  pages={332-49}
}
Open fractures are at risk of serious infection and, if infected, require several surgical interventions and courses of systemic antibiotics. We investigated a new injectable formulation that simultaneously hardens in vivo to form a porous scaffold for bone repair and delivers antibiotics at high concentrations to the local site of infection. Duration of antimicrobial activity against Staphylococcus aureus was determined using the serial plate transfer test. Ultimate compressive strength and… CONTINUE READING

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