A biochemically defined system for coding joint formation in V(D)J recombination.

Abstract

V(D)J recombination is one of the most complex DNA transactions in biology. The RAG complex makes double-stranded breaks adjacent to signal sequences and creates hairpin coding ends. Here, we find that the kinase activity of the Artemis:DNA-PKcs complex can be activated by hairpin DNA ends in cis, thereby allowing the hairpins to be nicked and then to… (More)
DOI: 10.1016/j.molcel.2008.05.029

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