A biochemical mechanism of the ototoxic interaction between neomycin and ethacrynic acid.

Abstract

The effects of neomycin on tissue levels of ethacrynic acid was studied in vivo and in vitro. In vitro, the addition of neomycin to incubations of synaptosomes and inner ear tissues of guinea pigs raised the concentration of bound ethacrynate approximately two-fold. In vivo, radioactive ethacrynate was determined in the inner ear of mice by radioautography… (More)

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.

Slides referencing similar topics