• Corpus ID: 34986464

A biochemical investigation into the inhibitory effects of glucosamine and N-acetylclucosamine on the aggregation in vitro of embryonic chick muscle cells.

  title={A biochemical investigation into the inhibitory effects of glucosamine and N-acetylclucosamine on the aggregation in vitro of embryonic chick muscle cells.},
  author={Clive Lloyd and Richard B. Kemp},
  journal={Journal of cell science},
  volume={9 1},
  • C. LloydR. Kemp
  • Published 1 July 1971
  • Biology, Chemistry
  • Journal of cell science
The effect of glucosamine and N -acetylglucosamine on aggregation and energy metabolism was investigated over an 8-h period in cells dissociated by 0.25% (w/v) trypsin from the skeletal muscle of 9-day-old chick embryos. At 8 h, 0.023 M glucosamine and N -acetylglucosamine inhibited the aggregation of cells suspended in Eagle9s minimal essential medium by 18.9% and 16.4% respectively, as judged on a basis of aggregate size. Glucosamine and N -acetylglucosamine reduced the cellular ATP level by… 

Effects of cytochalasins on the initial aggregation in vitro of embryonic chick cells.

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Studies on the mechanism underlying the inhibition by puromycin of cell aggregation in vitro.

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  • R. Kemp
  • Biology
    Journal of cell science
  • 1970
Embryonic chick muscle cells were used to investigate the effect of removing cell-surface sialic acids on cell aggregation in vitro and Interpretation of the results in the light of current theories of cell adhesion failed to give support to the concept of adhesion by physical forces.

Inhibitory effect of d-glucosamine and other sugar analogs on the viability and transplantability of ascites tumor cells.

d-Glucosamine has been shown to have a powerful cytotoxic effect on various ascites tumor lines, resulting in a decrease in viability and transplantability of the neoplastic cells, and d-Mannose was the only neutral sugar showing a cytot toxic effect on ascite tumor cells.