A biochemical, histochemical, and electron microscopic study on the effects of iron-loading on the hearts of mice.

@article{Bartfay1999ABH,
  title={A biochemical, histochemical, and electron microscopic study on the effects of iron-loading on the hearts of mice.},
  author={Wally Joseph Bartfay and Jagdish W Butany and Denis C. Lehotay and Michael Sole and Dongming Hou and Emma Bartfay and Peter Liu},
  journal={Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology},
  year={1999},
  volume={8 6},
  pages={305-14}
}
Acute iron poisoning and chronic iron overload are well-known causes of myocardial failure. Although the exact mechanism is not known, excess iron-catalyzed free radical generation is conjectured to play a role in damaging the myocardium and altering cardiac function. We report here on the effects of acute and chronic iron-loading on the total iron concentration, glutathione peroxidase activity, and cytotoxic aldehyde production in the heart of a murine model (n = 35). Light microscopic… CONTINUE READING

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