A bioactive drug quantitation based approach for the detection of anti-drug neutralizing antibodies in human serum.

Abstract

We describe in this paper a novel approach for the detection of neutralizing antibodies (NAbs) and the assessment of their impact on drug exposure. This approach is based on an in-vitro cell-based bioassay utilizing receptor tyrosine phosphorylation as a cellular endpoint and comprises of two assay formats: a quantitative assay for measurement of bioactive… (More)
DOI: 10.1016/j.jim.2009.04.005

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Cite this paper

@article{Hu2009ABD, title={A bioactive drug quantitation based approach for the detection of anti-drug neutralizing antibodies in human serum.}, author={Jenny Hu and Shalini Gupta and Steve J. Swanson and Yao Zhuang}, journal={Journal of immunological methods}, year={2009}, volume={345 1-2}, pages={70-9} }