A bio-chemo-mechanical model for cell contractility.

  title={A bio-chemo-mechanical model for cell contractility.},
  author={Vikram S. Deshpande and Robert M. McMeeking and Anthony G. Evans},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 38},
A general model for the contractility of cells is presented that accounts for the dynamic reorganization of the cytoskeleton. The model is motivated by three key biochemical processes: (i) an activation signal that triggers actin polymerization and myosin phosphorylation, (ii) the tension-dependent assembly of the actin and myosin into stress fibers, and (iii) the cross-bridge cycling between the actin and myosin filaments that generates the tension. Simple relations are proposed to model these… CONTINUE READING
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