A bias-reducing strategy in profiling small RNAs using Solexa.

  title={A bias-reducing strategy in profiling small RNAs using Solexa.},
  author={Guihua Sun and Xiwei Wu and Jinhui Wang and Haiqing Li and Xuejun Li and Hanlin Gao and John Rossi and Yun Yen},
  volume={17 12},
Small RNAs (smRNAs) encompass several different classes of short noncoding RNAs. Progress in smRNA research and applications has coincided with the advance of techniques to detect them. Next-generation sequencing technologies are becoming the preferred smRNA profiling method because of their high-throughput capacity and digitized results. In our small RNA profiling study using Solexa, we observed serious biases introduced by the 5' adaptors in small RNA species coverage and abundance; therefore… CONTINUE READING
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