A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2.

@article{Davare2001ABA,
  title={A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2.},
  author={Monika A. Davare and Vladimir Avdonin and Duane D. Hall and Erik M. Peden and Alain Burette and Richard J. Weinberg and Mary C Horne and Toshinori Hoshi and Johannes W Hell},
  journal={Science},
  year={2001},
  volume={293 5527},
  pages={
          98-101
        }
}
The existence of a large number of receptors coupled to heterotrimeric guanine nucleotide binding proteins (G proteins) raises the question of how a particular receptor selectively regulates specific targets. We provide insight into this question by identifying a prototypical macromolecular signaling complex. The beta(2) adrenergic receptor was found to be directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(v)1.2. This complex also contained a G protein… CONTINUE READING
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