A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease.

@article{Janus2000ABP,
  title={A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease.},
  author={Christopher George Janus and Jacqueline Pearson and JoAnne McLaurin and Paul M. Mathews and Ying Zi Jiang and Stephen D Schmidt and Muhammad Azhar Chishti and P. Scott Horne and Donna E. Heslin and Janet E French and Howard T. J. Mount and Ralph A. Nixon and Marc H Mercken and Catherine Racicot Bergeron and Paul E. Fraser and Peter St George-Hyslop and David Westaway},
  journal={Nature},
  year={2000},
  volume={408 6815},
  pages={
          979-82
        }
}
Much evidence indicates that abnormal processing and extracellular deposition of amyloid-beta peptide (A beta), a proteolytic derivative of the beta-amyloid precursor protein (betaAPP), is central to the pathogenesis of Alzheimer's disease (reviewed in ref. 1). In the PDAPP transgenic mouse model of Alzheimer's disease, immunization with A beta causes a marked reduction in burden of the brain amyloid. Evidence that A beta immunization also reduces cognitive dysfunction in murine models of… CONTINUE READING

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