A beta fibrillogenesis: kinetic parameters for fibril formation from congo red binding.

@article{Inouye2000ABF,
  title={A beta fibrillogenesis: kinetic parameters for fibril formation from congo red binding.},
  author={Hideyo Inouye and Daniel A. Kirschner},
  journal={Journal of structural biology},
  year={2000},
  volume={130 2-3},
  pages={123-9}
}
Using Scatchard analysis, we have formulated as a function of time and pH the relationship between the binding of Congo red to Alzheimer's beta-amyloid and the aggregation number (i.e., monomer concentration within fibrils) as defined by nucleation-dependent self-assembly. This provides a basis on which to determine the kinetic parameters for fibril formation from the observed concentration of bound Congo red. 

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