A benzodiazepine recognition site associated with the non-NMDA glutamate receptor

@article{Zorumski1993ABR,
  title={A benzodiazepine recognition site associated with the non-NMDA glutamate receptor},
  author={Charles F Zorumski and Kelvin A. Yamada and M. T. Price and John W. Olney},
  journal={Neuron},
  year={1993},
  volume={10},
  pages={61-67}
}
GYKI 52466 is a benzodiazepine molecule that has muscle relaxant and anticonvulsant properties not attributable to a gamma-aminobutyric acid receptor-mediated mechanism. Here it is shown that GYKI 52466 exerts no blocking action at N-methyl-D-aspartate (NMDA) glutamate receptors, but acts noncompetitively to block ion currents and associated excitotoxicity, including ischemic neuronal degeneration, mediated through non-NMDA glutamate receptors. The inhibition of non-NMDA responses by GYKI 52466… CONTINUE READING

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