A benzimidazole derivative exhibiting antitumor activity blocks EGFR and HER2 activity and upregulates DR5 in breast cancer cells

@inproceedings{Chu2015ABD,
  title={A benzimidazole derivative exhibiting antitumor activity blocks EGFR and HER2 activity and upregulates DR5 in breast cancer cells},
  author={Bi-zhu Chu and Feng Liu and Lu-lu Li and Changjun Ding and Kang Chen and Qin-sheng Sun and Zhi-fa Shen and Ying Tan and Chibing Tan and Yuchen Jiang},
  booktitle={Cell Death and Disease},
  year={2015}
}
Aberrant expression or function of epidermal growth factor receptor (EGFR) or the closely related human epidermal growth factor receptor 2 (HER2) can promote cell proliferation and survival, thereby contributing to tumorigenesis. Specific antibodies and low-molecular-weight tyrosine kinase inhibitors of both proteins are currently in clinical trials for cancer treatment. Benzimidazole derivatives possess diverse biological activities, including antitumor activity. However, the anticancer… CONTINUE READING

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Role of epidermal growth factor receptor in breast cancer

Breast Cancer Research and Treatment • 2012
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