A benefit-risk assessment of the use of proton pump inhibitors in the elderly.

@article{Masclee2014ABA,
  title={A benefit-risk assessment of the use of proton pump inhibitors in the elderly.},
  author={Gwen M C Masclee and Miriam C. J. M. Sturkenboom and Ernst J Kuipers},
  journal={Drugs & aging},
  year={2014},
  volume={31 4},
  pages={
          263-82
        }
}
Proton pump inhibitors (PPIs) are among the most commonly used drugs worldwide, and their intake increases with age. Despite a relatively safe profile, a range of studies have reported associations between use of PPIs and various adverse events. The most important adverse events, such as pneumonia, bone fractures, bacterial enteric infections, and diminished vitamin absorption are critically discussed in this review in view of the body of evidence, including underlying biological mechanisms… CONTINUE READING
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