A bell-shaped dependence between amyloidosis and GABA accumulation in astrocytes in a mouse model of Alzheimer's disease

@article{Brawek2018ABD,
  title={A bell-shaped dependence between amyloidosis and GABA accumulation in astrocytes in a mouse model of Alzheimer's disease},
  author={Bianca Brawek and Robert A Chesters and Daniel Klement and Johannes M{\"u}ller and O. V. Garaschuk},
  journal={Neurobiology of Aging},
  year={2018},
  volume={61},
  pages={187-197}
}
Functioning at the interface between the nervous and immune systems, in the amyloid-depositing brain, astrocytes become hypertrophic and accumulate around senile plaques. Moreover, hippocampal astrocytes upregulate their γ-aminobutyric acid (GABA) content and enhance tonic inhibition, likely causing local circuit imbalance. It remains, however, unclear whether this effect is hippocampus specific and how it is regulated during disease progression. Here, we studied changes in astrocytic… CONTINUE READING