A behavioral genetics approach to understanding D1 receptor involvement in phasic dopamine signaling.

@article{Wall2011ABG,
  title={A behavioral genetics approach to understanding D1 receptor involvement in phasic dopamine signaling.},
  author={Valerie Z. Wall and Jones G. Parker and Jonathan Paul Fadok and Martin Darvas and Larry S Zweifel and Richard D Palmiter},
  journal={Molecular and cellular neurosciences},
  year={2011},
  volume={46 1},
  pages={21-31}
}
Dopamine-producing neurons fire with both basal level tonic patterns and phasic bursts. Varying affinities of the five dopamine receptors have led to a hypothesis that higher affinity receptors are primarily activated by basal level tonic dopamine, while lower affinity receptors may be tuned to be sensitive to higher levels caused by phasic bursts. Genetically modified mice provide a method to begin to probe this hypothesis. Here we discuss three mouse models. Dopamine-deficient mice were used… CONTINUE READING

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