A behavioral and molecular analysis of ketamine in zebrafish.

@article{Zakhary2011ABA,
  title={A behavioral and molecular analysis of ketamine in zebrafish.},
  author={Sherry M. Zakhary and Diana Ayubcha and Farah Jamal Ansari and Kiran Kamran and Mehwish Karim and Joerg R. Leheste and Judith M. Horowitz and German Torres},
  journal={Synapse},
  year={2011},
  volume={65 2},
  pages={160-7}
}
Ketamine exerts powerful anesthetic, psychotic, and antidepressant effects in both healthy volunteers and clinically depressed patients. Although ketamine targets particular glutamate receptors, there is a dearth of evidence for additional, alternative molecular substrates for the behavioral actions of this N-methyl-D-aspartate (NMDA) receptor antagonist drug. Here, we provide behavioral and molecular evidence for the actions of ketamine using a new vertebrate model for psychiatric disorders… CONTINUE READING

4 Figures & Tables

Connections & Topics

Mentioned Connections BETA
Ketamine exerts powerful anesthetic , psychotic , and antidepressant effects in both healthy volunteers and clinically depressed patients .
Ketamine exerts powerful anesthetic , psychotic , and antidepressant effects in both healthy volunteers and clinically depressed patients .
Although ketamine targets particular glutamate receptors , there is a dearth of evidence for additional , alternative molecular substrates for the behavioral actions of this N - methyl - D - aspartate ( NMDA ) receptor antagonist drug .
Although ketamine targets particular glutamate receptors , there is a dearth of evidence for additional , alternative molecular substrates for the behavioral actions of this N - methyl - D - aspartate ( NMDA ) receptor antagonist drug .
Although ketamine targets particular glutamate receptors , there is a dearth of evidence for additional , alternative molecular substrates for the behavioral actions of this N - methyl - D - aspartate ( NMDA ) receptor antagonist drug .
Although ketamine targets particular glutamate receptors , there is a dearth of evidence for additional , alternative molecular substrates for the behavioral actions of this N - methyl - D - aspartate ( NMDA ) receptor antagonist drug .
Although ketamine targets particular glutamate receptors , there is a dearth of evidence for additional , alternative molecular substrates for the behavioral actions of this N - methyl - D - aspartate ( NMDA ) receptor antagonist drug .
KetamineContraindicated with diseasePsychotic Disorders
Subanesthetic doses of ketamine produced a variety of abnormal behaviors in zebrafish that were qualitatively analogous to those previously measured in humans and rodents treated with drugs that produce transient psychosis .
Ketamine exerts powerful anesthetic , psychotic , and antidepressant effects in both healthy volunteers and clinically depressed patients .
Although ketamine targets particular glutamate receptors , there is a dearth of evidence for additional , alternative molecular substrates for the behavioral actions of this N - methyl - D - aspartate ( NMDA ) receptor antagonist drug .
All Topics