A behavioral analysis of dentate gyrus function.

@article{Kesner2007ABA,
  title={A behavioral analysis of dentate gyrus function.},
  author={Raymond P. Kesner},
  journal={Progress in brain research},
  year={2007},
  volume={163},
  pages={
          567-76
        }
}
  • R. Kesner
  • Published 2007
  • Psychology, Biology
  • Progress in brain research
View on PubMed
doi.org
208 Citations
Highly Influential Citations
20
Background Citations
105
Methods Citations
15
Results Citations
7

208 Citations

Molecular mechanisms within the dentate gyrus and the perirhinal cortex interact during discrimination of similar nonspatial memories
TLDR
A complex interaction between plasticity mechanisms in the PrH and DG for nonspatial pattern separation is revealed and the Prh is posited as the key structure where unique object representations are stored.
Temporal associations for spatial events: The role of the dentate gyrus
Pattern separation in the dentate gyrus: A role for the CA3 backprojection
TLDR
A simple CA3 network model is considered, and it is hypothesize that CA3 backprojections might play an important role in hippocampal function, and shows that the DG‐CA3 model with backprojection provides a better fit to empirical data than a model without back projections.
The role of hippocampal subregions in memory for stimulus associations
Resolving New Memories: A Critical Look at the Dentate Gyrus, Adult Neurogenesis, and Pattern Separation
A Computational Model Of Episodic Memory Encoding In Dentate Gyrus Hippocampus Sub Region As Pattern Separator Using ART Neural Network
TLDR
The proposed model is capable of achieving high level of pattern encoding and separation and the separation achieved for different episodes and events shown by the results are very good depending upon the vigilance parameter of the model.
Flexible encoding of objects and space in single cells of the dentate gyrus
TLDR
Recording from the dentate gyrus reveals the capacity of DG cells to detect small changes in the environment, while preserving a stable spatial representation of the overall context.
Role of dentate gyrus in aligning internal spatial map to external landmark.
Humans and animals form internal representations of external space based on their own body movement (dead reckoning) as well as external landmarks. It is poorly understood, however, how different…
Role of the dentate gyrus in mediating object-spatial configuration recognition
Selective lesions of the dentate gyrus produce disruptions in place learning for adjacent spatial locations
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References

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A Behavioral Assessment of Hippocampal Function Based on a Subregional Analysis
TLDR
Whether specific subregions (dentate gyrus, CA3, and CA1) of the hippocampus provide unique contributions to specific processes associated with intrinsic information processing exemplified by novelty detection, encoding, pattern separation, pattern association, pattern completion, retrieval, short-term memory and intermediate- term memory is determined.
A computational theory of hippocampal function, and empirical tests of the theory
Encoding versus retrieval of spatial memory: Double dissociation between the dentate gyrus and the perforant path inputs into CA3 in the dorsal hippocampus
TLDR
The results suggest that the two major afferent inputs of CA3 may contribute differentially to encoding and retrieval of spatial memory.
Differential roles of dorsal hippocampal subregions in spatial working memory with short versus intermediate delay.
TLDR
A dynamic interaction among the dorsal hippocampal subregions in processing spatial working memory is suggested, with the time window of a task recognized as an essential controlling factor.
A theory of hippocampal function in memory
  • E. Rolls
  • Biology, Psychology
    Hippocampus
  • 1996
TLDR
Key hypotheses are that the CA3 pyramidal cells operate as a single autoassociation network to store new episodic information as it arrives via a number of specialized preprocessing stages from many different association areas of the cerebral cortex, and that the dentate granule cell/mossy fiber system is important particularly during learning to help to produce a new pattern of firing in theCA3 cells for each episode.
Localization of function within the dorsal hippocampus: the role of the CA3 subregion in paired-associate learning.
TLDR
The data indicate that rats with DG or CA1 lesions learned the tasks as well as controls; however, CA3-lesioned rats were impaired in learning the tasks, suggesting the CA3 subregion of the dorsal hippocampus contains a mechanism to support paired-associate learning.
Differential contribution of NMDA receptors in hippocampal subregions to spatial working memory
TLDR
Evidence is presented that NMDA receptors in CA3 are required in a situation in which spatial representation needs to be reorganized, whereas the NMDA receptor in CA1 and/or the dentate gyrus are more involved in acquiring memory that needs to been retrieved after a delay period exceeding a short-term range.
Disconnection analysis of CA3 and DG in mediating encoding but not retrieval in a spatial maze learning task.
TLDR
Animals receiving CA3 lesions were impaired in encoding, not retrieval, on the modified Hebb-Williams maze--similar to a group that received DG lesions, suggesting the possibility that CA3 and DG are working together to mediate encoding processes.
The role of the direct perforant path input to the CA1 subregion of the dorsal hippocampus in memory retention and retrieval
TLDR
It is demonstrated that local infusion of the nonselective dopamine agonist, apomorphine, into the CA1 subregion of awake animals produces impairments in between‐day retention and retrieval, and the possibility of a more fundamental role for EC‐CA1 synaptic transmission in terms of intermediate‐term, but not short‐term spatial memory is suggested.
Hippocampal CA3 NMDA Receptors Are Crucial for Memory Acquisition of One-Time Experience
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