A beating heart cell model to predict cardiotoxicity: effects of the dietary supplement ingredients higenamine, phenylethylamine, ephedrine and caffeine.

@article{Calvert2015ABH,
  title={A beating heart cell model to predict cardiotoxicity: effects of the dietary supplement ingredients higenamine, phenylethylamine, ephedrine and caffeine.},
  author={Richard J. Calvert and Sanah N. Vohra and Martine S. Ferguson and Paddy L. Wiesenfeld},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2015},
  volume={78},
  pages={207-13}
}
Some dietary supplements may contain cardiac stimulants and potential cardiotoxins. In vitro studies may identify ingredients of concern. A beating human cardiomyocyte cell line was used to evaluate cellular effects following phenylethylamine (PEA), higenamine, ephedrine or caffeine treatment. PEA and higenamine exposure levels simulated published blood levels in humans or animals after intravenous administration. Ephedrine and caffeine levels approximated published blood levels following human… CONTINUE READING

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