A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex.

@article{Chaudhuri2009ABP,
  title={A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex.},
  author={Rittik Chaudhuri and Rafael Mattera and O. Wolf Lindwasser and Margaret S Robinson and Juan S Bonifacino},
  journal={Journal of virology},
  year={2009},
  volume={83 6},
  pages={
          2518-30
        }
}
A critical function of the human immunodeficiency virus type 1 Nef protein is the downregulation of CD4 from the surfaces of infected cells. Nef is believed to act by linking the cytosolic tail of CD4 to the endocytic machinery, thereby increasing the rate of CD4 internalization. In support of this model, weak binary interactions between CD4, Nef, and the endocytic adaptor complex, AP-2, have been reported. In particular, dileucine and diacidic motifs in the C-terminal flexible loop of Nef have… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 28 CITATIONS

Mechanisms of HIV-1 Nef Function and Intracellular Signaling

  • Journal of Neuroimmune Pharmacology
  • 2011
VIEW 7 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED