A base pair between tRNA and 23S rRNA in the peptidyl transferase centre of the ribosome

@article{Samaha1995ABP,
  title={A base pair between tRNA and 23S rRNA in the peptidyl transferase centre of the ribosome},
  author={Raymond R. Samaha and Rachel Green and Harry F. Noller},
  journal={Nature},
  year={1995},
  volume={377},
  pages={309-314}
}
Interaction of the conserved CCA terminus of tRNA with rRNA in the peptidyl transferase P site has been studied by in vitro genetics. A Watson–Crick G–C pair between G2252 in a conserved hairpin loop of 23S rRNA and C74 at the acceptor end of tRNA is required for proper functional interaction of the CCA end of tRNA with the ribosomal P site. These findings establish a direct role for 23S rRNA in protein synthesis.