A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts

@inproceedings{Leedham2013ABG,
  title={A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts},
  author={Simon John Leedham and Pedro Rodenas-Cuadrado and Kimberley M. Howarth and Annabelle Lewis and Sreelakshmi Mallappa and Stefania Segditsas and Hayley Dixon Gary Davis and Rosemary Jeffery and Manuel Rodriguez-Justo and Satish Keshav and Simon P L Travis and Trevor A Graham and James East and Susan K. Clark and Ian P M Tomlinson},
  booktitle={Gut},
  year={2013}
}
OBJECTIVE Wnt signalling is critical for normal intestinal development and homeostasis. Wnt dysregulation occurs in almost all human and murine intestinal tumours and an optimal but not excessive level of Wnt activation is considered favourable for tumourigenesis. The authors assessed effects of pan-intestinal Wnt activation on tissue homeostasis, taking into account underlying physiological Wnt activity and stem-cell number in each region of the bowel. DESIGN The authors generated mice that… CONTINUE READING
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b - catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis

  • W vanVeelen, NH Le, W Helvensteijn
  • Gut
  • 2011

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