A balance of interleukin-12 and -23 in cancer.

  title={A balance of interleukin-12 and -23 in cancer.},
  author={Shin Foong Ngiow and Michele W. L. Teng and Mark J Smyth},
  journal={Trends in immunology},
  volume={34 11},
Interleukin (IL)-12 and IL-23 share the IL-12p40 molecule. IL-12 promotes T helper (Th)1 immunity and IL-23 promotes Th17 immunity, and it has recently become apparent that the balance between IL-12 and IL-23 is important in carcinogenesis. A series of studies demonstrated that, where tumor initiation, growth, and metastasis are concerned, IL-12 may act independently of interferon (IFN)-γ, and IL-23 independently of IL-17A. This review explores the activity of IL-23 in carcinogenesis. In the… CONTINUE READING
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