A balance of FGF, BMP and WNT signalling positions the future placode territory in the head.

@article{Litsiou2005ABO,
  title={A balance of FGF, BMP and WNT signalling positions the future placode territory in the head.},
  author={Anna Litsiou and Sven Hanson and Andrea Streit},
  journal={Development},
  year={2005},
  volume={132 18},
  pages={4051-62}
}
The sensory nervous system in the vertebrate head arises from two different cell populations: neural crest and placodal cells. By contrast, in the trunk it originates from neural crest only. How do placode precursors become restricted exclusively to the head and how do multipotent ectodermal cells make the decision to become placodes or neural crest? At neural plate stages, future placode cells are confined to a narrow band in the head ectoderm, the pre-placodal region (PPR). Here, we identify… CONTINUE READING
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