A balance between Tel1 and Rif2 activities regulates nucleolytic processing and elongation at telomeres.

Abstract

Generation of G-strand overhangs at Saccharomyces cerevisiae yeast telomeres depends primarily on the MRX (Mre11-Rad50-Xrs2) complex, which is also necessary to maintain telomere length by recruiting the Tel1 kinase. MRX physically interacts with Rif2, which inhibits both resection and elongation of telomeres. We provide evidence that regulation of telomere… (More)
DOI: 10.1128/MCB.06547-11

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@article{Martina2012ABB, title={A balance between Tel1 and Rif2 activities regulates nucleolytic processing and elongation at telomeres.}, author={Marina Martina and Michela Clerici and Veronica Baldo and Diego Bonetti and G. Lucchini and Maria Pia Longhese}, journal={Molecular and cellular biology}, year={2012}, volume={32 9}, pages={1604-17} }