A bacterial tyrosine aminomutase proceeds through retention or inversion of stereochemistry to catalyze its isomerization reaction.

@article{Wanninayake2013ABT,
  title={A bacterial tyrosine aminomutase proceeds through retention or inversion of stereochemistry to catalyze its isomerization reaction.},
  author={Udayanga S Wanninayake and Kevin C. Walker},
  journal={Journal of the American Chemical Society},
  year={2013},
  volume={135 30},
  pages={11193-204}
}
β-Amino acids are biologically active compounds of interest in medicinal chemistry. A class I lyase-like family of aminomutases isomerizes (S)-α-arylalanines to the corresponding β-amino acids by exchange of the NH2/H pair. This family uses a 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO) group within the active site to initiate the reaction. The… CONTINUE READING