A bacterial type III effector family uses the papain-like hydrolytic activity to arrest the host cell cycle.

Abstract

Pathogenic bacteria deliver effector proteins into host cells through the type III secretion apparatus to modulate the host function. We identify a family of proteins, homologous to the type III effector Cif from enteropathogenic Escherichia coli, in pathogens including Yersinia, Photorhabdus, and Burkholderia that contain functional type III secretion… (More)
DOI: 10.1073/pnas.0900212106

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