A bacterial protein enhances the release and efficacy of liposomal cancer drugs.

@article{Cheong2006ABP,
  title={A bacterial protein enhances the release and efficacy of liposomal cancer drugs.},
  author={Ian Cheong and Xin Huang and C Bettegowda and Luis A Diaz and Kenneth W. Kinzler and Shibin Zhou and Bert Vogelstein},
  journal={Science},
  year={2006},
  volume={314 5803},
  pages={1308-11}
}
Clostridium novyi-NT is an anaerobic bacterium that can infect hypoxic regions within experimental tumors. Because C. novyi-NT lyses red blood cells, we hypothesized that its membrane-disrupting properties could be exploited to enhance the release of liposome-encapsulated drugs within tumors. Here, we show that treatment of mice bearing large, established tumors with C. novyi-NT plus a single dose of liposomal doxorubicin often led to eradication of the tumors. The bacterial factor responsible… CONTINUE READING
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