A bacterial inhibitor of animal protein kinases

  title={A bacterial inhibitor of animal protein kinases},
  author={Mustapha Dadssi and Dr. Alain J. Cozzone},
  journal={Current Microbiology},
Cellular extracts ofEscherichia coli severely impair the protein-phosphorylating activity in vitro of animal enzymes of both the casein-kinase type and the histone-kinase type. This blockade is due to a protein, probably dimeric, acting as a noncompetitive inhibitor, which has been purified to near-homogeneity from the soluble fraction of bacterial cells by… CONTINUE READING