A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes.

  title={A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes.},
  author={Hiroki Nagai and Jonathan C. Kagan and Xinjun Cindy Zhu and Richard A. Kahn and Craig R Roy},
  volume={295 5555},
The intracellular pathogen Legionella pneumophila subverts vesicle traffic in eukaryotic host cells to create a vacuole that supports replication. The dot/icm genes encode a protein secretion apparatus that L. pneumophila require for biogenesis of this vacuole. Here we show that L. pneumophila produce a protein called RalF that functions as an exchange factor for the ADP ribosylation factor (ARF) family of guanosine triphosphatases (GTPases). The RalF protein is required for the localization of… CONTINUE READING
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