A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi

  title={A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi},
  author={S. Casjens and N. Palmer and Ren{\'e} Van Vugt and Wai Mun Huang and B. Stevenson and P. Rosa and R. Lathigra and G. Sutton and J. Peterson and R. Dodson and D. Haft and E. Hickey and M. Gwinn and O. White and Claire M. Fraser},
  journal={Molecular Microbiology},
  • S. Casjens, N. Palmer, +12 authors Claire M. Fraser
  • Published 2000
  • Biology, Medicine
  • Molecular Microbiology
  • We have determined that Borrelia burgdorferi strain B31 MI carries 21 extrachromosomal DNA elements, the largest number known for any bacterium. Among these are 12 linear and nine circular plasmids, whose sequences total 610 694 bp. We report here the nucleotide sequence of three linear and seven circular plasmids (comprising 290 546 bp) in this infectious isolate. This completes the genome sequencing project for this organism; its genome size is 1 521 419 bp (plus about 2000 bp of undetermined… CONTINUE READING
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