A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis.

@article{Dong2010ABE,
  title={A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis.},
  author={Na Dong and LiPing Liu and Feng Shao},
  journal={The EMBO journal},
  year={2010},
  volume={29 8},
  pages={
          1363-76
        }
}
Bacterial pathogens often harbour a type III secretion system (TTSS) that injects effector proteins into eukaryotic cells to manipulate host processes and cause diseases. Identification of host targets of bacterial effectors and revealing their mechanism of actions are crucial for understating bacterial virulence. We show that EspH, a type III effector conserved in enteric bacterial pathogens including enteropathogenic Escherichia coli (EPEC), enterohaemorrhagic E. coli and Citrobacter… CONTINUE READING
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