A background Ca2+ entry pathway mediated by TRPC1/TRPC4 is critical for development of pathological cardiac remodelling.

@article{Londoo2015ABC,
  title={A background Ca2+ entry pathway mediated by TRPC1/TRPC4 is critical for development of pathological cardiac remodelling.},
  author={Juan E Camacho Londo{\~n}o and Qinghai Tian and Karin P. Hammer and Laura Schroeder and Julia Camacho Londo{\~n}o and Jan Christian Reil and Tao He and Martin Oberhofer and Stefanie Mannebach and Ilka Mathar and Stephan Ernst Philipp and Wiebke Tabellion and Frank Schweda and Alexander Dietrich and Lars Kaestner and Ulrich Laufs and Lutz Birnbaumer and Veit Flockerzi and Marc Freichel and Peter Lipp},
  journal={European heart journal},
  year={2015},
  volume={36 33},
  pages={2257-66}
}
AIMS Pathological cardiac hypertrophy is a major predictor for the development of cardiac diseases. It is associated with chronic neurohumoral stimulation and with altered cardiac Ca(2+) signalling in cardiomyocytes. TRPC proteins form agonist-induced cation channels, but their functional role for Ca(2+) homeostasis in cardiomyocytes during fast cytosolic Ca(2+) cycling and neurohumoral stimulation leading to hypertrophy is unknown. METHODS AND RESULTS In a systematic analysis of multiple… CONTINUE READING
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