• Published 2008

A b-Lactam Antibiotic Dampens Excitotoxic Inflammatory CNS Damage in a Mouse Model of Multiple Sclerosis

@inproceedings{Melzer2008ABA,
  title={A b-Lactam Antibiotic Dampens Excitotoxic Inflammatory CNS Damage in a Mouse Model of Multiple Sclerosis},
  author={Nico Melzer and Sven G. Meuth and Delany Torres-Salazar and Stefan Bittner and Alla L. Zozulya and Christian Weidenfeller and Alexandra Kotsiari and Martin Stangel and Christoph Fahlke and Heinz S. Wiendl},
  year={2008}
}
In multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), impairment of glial ‘‘Excitatory Amino Acid Transporters’’ (EAATs) together with an excess glutamate-release by invading immune cells causes excitotoxic damage of the central nervous system (CNS). In order to identify pathways to dampen excitotoxic inflammatory CNS damage, we assessed the effects of a b-lactam antibiotic, ceftriaxone, reported to enhance expression of glial EAAT2, in ‘‘Myelin… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 53 REFERENCES

Glutamate excitotoxicity in a model of multiple sclerosis

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Passage of cefotaxime and ceftriaxone into cerebrospinal fluid of patients with uninflamed meninges.

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Glutamate receptor expression in multiple sclerosis lesions.

VIEW 1 EXCERPT