A Zebrafish Model for the Shwachman-Diamond Syndrome (SDS)

@article{Venkatasubramani2008AZM,
  title={A Zebrafish Model for the Shwachman-Diamond Syndrome (SDS)},
  author={Narayanan Venkatasubramani and Alan N Mayer},
  journal={Pediatric Research},
  year={2008},
  volume={63},
  pages={348-352}
}
The Shwachman-Diamond syndrome (SDS) is characterized by exocrine pancreatic insufficiency, neutrophil defect, and skeletal abnormalities. The molecular basis for this syndrome was recently identified as a defect in a novel nucleolar protein termed the Shwachman-Bodian-Diamond syndrome (SBDS) protein. Beyond human pathologic descriptions, there are little data addressing the role of SBDS during pancreas and granulocytes development. We hypothesize that sbds gene function is essential for… CONTINUE READING