A Zebrafish Genetic Screen Identifies Neuromedin U as a Regulator of Sleep/Wake States

  title={A Zebrafish Genetic Screen Identifies Neuromedin U as a Regulator of Sleep/Wake States},
  author={Cindy N. Chiu and Jason Rihel and Daniel A Lee and Chanpreet Singh and Eric A. Mosser and Shijia Chen and Viveca Sapin and Uyen Thi Phuong Pham and Jae Engle and Brett J. Niles and Christin J. Montz and Sridhara Chakravarthy and Steven Zimmerman and Kourosh Salehi-Ashtiani and Marc Vidal and Alexander F Schier and David A Prober},
Neuromodulation of arousal states ensures that an animal appropriately responds to its environment and engages in behaviors necessary for survival. However, the molecular and circuit properties underlying neuromodulation of arousal states such as sleep and wakefulness remain unclear. To tackle this challenge in a systematic and unbiased manner, we performed a genetic overexpression screen to identify genes that affect larval zebrafish arousal. We found that the neuropeptide neuromedin U (Nmu… CONTINUE READING
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