A Zebrafish Embryo Culture System Defines Factors that Promote Vertebrate Myogenesis across Species

@article{Xu2013AZE,
  title={A Zebrafish Embryo Culture System Defines Factors that Promote Vertebrate Myogenesis across Species},
  author={Cong Xu and Mohammadsharif Tabebordbar and Salvatore Iovino and Christie Ciarlo and Jingxia Liu and Alessandra Castiglioni and Emily J Price and Min Liu and Elisabeth R. Barton and C Ronald Kahn and Amy J. Wagers and Leonard I. Zon},
  journal={Cell},
  year={2013},
  volume={155},
  pages={909-921}
}
Ex vivo expansion of satellite cells and directed differentiation of pluripotent cells to mature skeletal muscle have proved difficult challenges for regenerative biology. Using a zebrafish embryo culture system with reporters of early and late skeletal muscle differentiation, we examined the influence of 2,400 chemicals on myogenesis and identified six that expanded muscle progenitors, including three GSK3β inhibitors, two calpain inhibitors, and one adenylyl cyclase activator, forskolin… CONTINUE READING
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