A Yin-Yang balancing act of the lin28/let-7 link in tumorigenesis.

@article{Ji2010AYB,
  title={A Yin-Yang balancing act of the lin28/let-7 link in tumorigenesis.},
  author={Junfang Ji and Xin Wei Wang},
  journal={Journal of hepatology},
  year={2010},
  volume={53 5},
  pages={974-5}
}
Multiple members of the let-7 family of miRNAs are often repressed in human cancers, thereby promoting oncogenesis by derepressing targets such as HMGA2, K-Ras and c-Myc. However, the mechanism by which let-7 miRNAs are coordinately repressed is unclear. The RNA-binding proteins lin28 and lin28B block let-7 precursors from being processed to mature miRNAs, suggesting that their overexpression might promote malignancy through repression of let-7. Here we show that lin28 and lin28B are… CONTINUE READING
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Lin28 promotes transformation and is associated with advanced human malignancies

  • SR Viswanathan, JT Powers, W Einhorn, Y Hoshida, TL Ng, S Toffanin
  • Nat Genet
  • 2009
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