A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system.

@article{Brodsky2010AYE,
  title={A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system.},
  author={Igor E Brodsky and Noah W Palm and Saheli Sadanand and Michelle B. Ryndak and Fayyaz Shiraz Sutterwala and Richard A Flavell and James B Bliska and Ruslan Medzhitov},
  journal={Cell host & microbe},
  year={2010},
  volume={7 5},
  pages={376-87}
}
Bacterial pathogens utilize pore-forming toxins or specialized secretion systems to deliver virulence factors to modulate host cell physiology and promote bacterial replication. Detection of these secretion systems or toxins, or their activities, by nucleotide-binding oligomerization domain leucine-rich repeat proteins (NLRs) triggers the assembly of inflammasomes, multiprotein complexes necessary for caspase-1 activation and host defense. Here we demonstrate that caspase-1 activation in… CONTINUE READING
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