A Yeast Catabolic Enzyme Controls Transcriptional Memory

@article{Zacharioudakis2007AYC,
  title={A Yeast Catabolic Enzyme Controls Transcriptional Memory},
  author={Ioannis Zacharioudakis and Thomas Gligoris and Dimitris Tzamarias},
  journal={Current Biology},
  year={2007},
  volume={17},
  pages={2041-2046}
}
It has been postulated that chromatin modifications can persist through mitosis and meiosis, thereby securing memory of transcriptional states. Whether these chromatin marks can self-propagate in progeny independently of relevant trans-acting factors is an important question in phenomena related to epigenesis. "Adaptive cellular memory" displayed by yeast cells offers a convenient system to address this question. The yeast GAL genes are slowly activated by Gal4 when cells are first exposed to… CONTINUE READING

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