A Y-box consensus sequence is required for basal expression of the human multidrug resistance (mdr1) gene.

@article{Goldsmith1993AYC,
  title={A Y-box consensus sequence is required for basal expression of the human multidrug resistance (mdr1) gene.},
  author={Merrill E. Goldsmith and M J Madden and Charles S. Morrow and Kenneth H. Cowan},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 8},
  pages={5856-60}
}
Basal transcription of the human multidrug resistance (mdr1) promoter was studied by chloramphenicol acetyltransferase (CAT) reporter fusion gene analysis in two parental and doxorubicin-resistant human tumor cell lines. Deletion of mdr1 DNA sequences to -89 relative to the start of transcription (at +1) had little effect on expression. Deletion of nucleotide sequences from -89 to -70, however, resulted in a 5-10-fold reduction in mdrCAT expression. DNase I footprint analysis demonstrated that… CONTINUE READING

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