A Xenopus oocyte beta subunit: evidence for a role in the assembly/expression of voltage-gated calcium channels that is separate from its role as a regulatory subunit.

@article{Tareilus1997AXO,
  title={A Xenopus oocyte beta subunit: evidence for a role in the assembly/expression of voltage-gated calcium channels that is separate from its role as a regulatory subunit.},
  author={E Tareilus and Maryline Roux and Ning Qin and Riccardo Olcese and Jing Zhou and Enrico Stefani and Lutz Birnbaumer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 5},
  pages={1703-8}
}
Two closely related beta subunit mRNAs (xo28 and xo32) were identified in Xenopus oocytes by molecular cloning. One or both appear to be expressed as active proteins, because: (i) injection of Xenopus beta antisense oligonucleotides, but not of sense or unrelated oligonucleotides, significantly reduced endogenous oocyte voltage-gated Ca2+ channel (VGCC) currents and obliterated VGCC currents that arise after injection of mammalian alpha1 cRNAs (alpha(1C) and alpha(1E)); (ii) coinjection of a… CONTINUE READING

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