A Wolbachia Symbiont in Aedes aegypti Limits Infection with Dengue, Chikungunya, and Plasmodium

@article{Moreira2009AWS,
  title={A Wolbachia Symbiont in Aedes aegypti Limits Infection with Dengue, Chikungunya, and Plasmodium},
  author={Luciano Andrade Moreira and I{\~n}aki Iturbe-Ormaetxe and Jason A. L. Jeffery and Guangjin Lu and Alyssa T. Pyke and Lauren M. Hedges and Bruno Coelho Rocha and Sonja Hall-Mendelin and Andrew Day and Markus Riegler and Leon E. Hugo and Karyn N. Johnson and Brian H. Kay and Elizabeth A. McGraw and Andrew F. Hurk and Peter A. Ryan and Scott L O'Neill},
  journal={Cell},
  year={2009},
  volume={139},
  pages={1268-1278}
}
Wolbachia are maternally inherited intracellular bacterial symbionts that are estimated to infect more than 60% of all insect species. While Wolbachia is commonly found in many mosquitoes it is absent from the species that are considered to be of major importance for the transmission of human pathogens. The successful introduction of a life-shortening strain of Wolbachia into the dengue vector Aedes aegypti that halves adult lifespan has recently been reported. Here we show that this same… Expand
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This work shows a correlation between innate immune priming and bacterial protection phenotypes, and raises the questions of whether Wolbachia may improve the ability of wild mosquitoes to survive pathogen infection or alter the natural composition of gut flora, and thus have broader consequences for host fitness. Expand
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TLDR
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Costs of Three Wolbachia Infections on the Survival of Aedes aegypti Larvae under Starvation Conditions
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It is found that all three Wolbachia infections reduce the survival of larvae relative to those that are uninfected, and the severity of the effect is concordant with previously characterized fitness costs to other life stages. Expand
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