A Whole Cell Pathway Screen Reveals Seven Novel Chemosensitizers to Combat Chloroquine Resistant Malaria

@article{Chng2013AWC,
  title={A Whole Cell Pathway Screen Reveals Seven Novel Chemosensitizers to Combat Chloroquine Resistant Malaria},
  author={Jun-Hong Ch'ng and Sachel Mok and Zbynek Bozdech and Martin J. Lear and Aicha Boudhar and Bruce M Russell and François H. Nosten and Kevin Shyong-Wei Tan},
  journal={Scientific Reports},
  year={2013},
  volume={3}
}
Due to the widespread prevalence of resistant parasites, chloroquine (CQ) was removed from front-line antimalarial chemotherapy in the 1990s despite its initial promise of disease eradication. Since then, resistance-conferring mutations have been identified in transporters such as the PfCRT, that allow for the efflux of CQ from its primary site of action, the parasite digestive vacuole. Chemosensitizing/chemoreversing compounds interfere with the function of these transporters thereby… 

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