A West Nile virus recombinant protein vaccine that coactivates innate and adaptive immunity.

@article{McDonald2007AWN,
  title={A West Nile virus recombinant protein vaccine that coactivates innate and adaptive immunity.},
  author={William J. F. McDonald and James W. Huleatt and Harald G. Foellmer and Duane D Hewitt and Jie Tang and Priyanka S. Desai and Albert Price and Andrea R Jacobs and Virginia N Takahashi and Yan Huang and Valerian Nakaar and Lena Alexopoulou and Erol Fikrig and Timothy J. Powell},
  journal={The Journal of infectious diseases},
  year={2007},
  volume={195 11},
  pages={1607-17}
}
A chimeric protein West Nile virus (WNV) vaccine capable of delivering both innate and adaptive immune signals was designed by fusing a modified version of bacterial flagellin (STF2 Delta ) to the EIII domain of the WNV envelope protein. This fusion protein stimulated interleukin-8 production in a Toll-like receptor (TLR)-5-dependent fashion, confirming appropriate in vitro TLR5 bioactivity, and also retained critical WNV-E-specific conformation-dependent neutralizing epitopes as measured by… CONTINUE READING

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