A Way Forward for Culturing Plasmodium vivax.

@article{Gunalan2020AWF,
  title={A Way Forward for Culturing Plasmodium vivax.},
  author={Karthigayan Gunalan and Emma H Rowley and L. Miller},
  journal={Trends in parasitology},
  year={2020}
}
Trager and Jensen established a method for culturing Plasmodium falciparum, a breakthrough for malaria research worldwide. Since then, multiple attempts to establish Plasmodium vivax in continuous culture have failed. Unlike P. falciparum, which can invade all aged erythrocytes, P. vivax is restricted to reticulocytes. Thus, a constant supply of reticulocytes is considered critical for continuous P. vivax growth in vitro. A critical question remains why P. vivax selectively invades… Expand
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