A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory.

@article{Soderling2007AWA,
  title={A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory.},
  author={Scott H Soderling and Eric S. Guire and Stefanie Kaech and Jon White and Fang Zhang and Kevin Schutz and Lorene K Langeberg and Gary Banker and Jacob Raber and John D Scott},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 2},
  pages={355-65}
}
The scaffolding protein WAVE-1 (Wiskott-Aldrich syndrome protein family member 1) directs signals from the GTPase Rac through the Arp2/3 complex to facilitate neuronal actin remodeling. The WAVE-associated GTPase activating protein called WRP is implicated in human mental retardation, and WAVE-1 knock-out mice have altered behavior. Neuronal time-lapse imaging, behavioral analyses, and electrophysiological recordings from genetically modified mice were used to show that WAVE-1 signaling… CONTINUE READING

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