A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains

  title={A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains},
  author={Catriona D. Good and Ingrid S. Johnsrude and John Ashburner and Richard N. A. Henson and Karl J. Friston and Richard S. Frackowiak},
Voxel-based-morphometry (VBM) is a whole-brain, unbiased technique for characterizing regional cerebral volume and tissue concentration differences in structural magnetic resonance images. We describe an optimized method of VBM to examine the effects of age on grey and white matter and CSF in 465 normal adults. Global grey matter volume decreased linearly with age, with a significantly steeper decline in males. Local areas of accelerated loss were observed bilaterally in the insula, superior… 

Figures and Tables from this paper

Brain volumes in healthy adults aged 40 years and over: a voxel-based morphometry study
These results support side-specific accelerated WM loss in men, and may help the better understanding of changes in regional brain structures associated with pathological aging.
Age-Related Gray and White Matter Changes in Normal Adult Brains
Normal aging is associated with both structural changes in many brain regions and functional declines in several cognitive domains with advancing age. Advanced neuroimaging techniques enable
Age-related changes in regional brain volume evaluated by atlas-based method
An atlas-based method is introduced as a methodological alternative that calculates absolute volume as a non-biased and semi-automatic whole-brain technique and has an advantage over the VBM method in its computability of absolute volume.
Adjusting for global effects in voxel-based morphometry: Gray matter decline in normal aging
Voxel-based morphometry in Alzheimer’s disease
Findings related to different AD stages and its prodrome, mild cognitive impairment are reviewed, including not only gray matter deficits in medial temporal structures as seen in former MRI studies of AD conducted using manual region-of-interest measurements, but also volume changes in several other brain regions not assessed in previous MRI studies.


Sex differences in brain aging: a quantitative magnetic resonance imaging study.
The results are generally consistent with the few published studies on sex differences in brain aging and suggest that, for at least some structures, aging effects may be more apparent in men than women.
Age and Gender Predict Volume Decline in the Anterior and Posterior Hippocampus in Early Adulthood
Results suggest a larger shrinkage for men of brain gray matter, with controversial observations being made for the HC, and underscores the need to include sociodemographic variables in functional and anatomical MRI designs.
Selective aging of the human cerebral cortex observed in vivo: differential vulnerability of the prefrontal gray matter.
Small but consistent rightward asymmetry was found in the whole cerebral hemispheres, superior parietal, fusiform and orbito-frontal cortices, postcentral and prefrontal white matter, and in the parietal white matter.
Age‐Related White Matter Atrophy in the Human Brain
The findings show that the age-related decline in brain volume is much more a question of white matter atrophy than of brain cortex atrophy, which could be an indirect indicator of nerve cell loss, since the volume of a nerve cell is much smaller than its myelinated fiber.
One-year age changes in MRI brain volumes in older adults.
Definition of the pattern and rate of longitudinal brain changes will facilitate the detection of pathological brain changes, which may be predictors of dementia, in nondemented older participants in the Baltimore Longitudinal Study of Aging.
Sex differences in aging of the human frontal and temporal lobes
Age-related reductions in both regions were greater in men than in women, demonstrating that sexual dimorphisms in human neuroanatomy are not fixed, but continue to change throughout adulthood.
Pathoclysis in aging human cerebral cortex: Evidence from in vivo MRI morphometry
The results of the reported studies support the notion of selective aging of cortical association areas accompanied by relative sparing of sensory cortices.
Gender differences in age effect on brain atrophy measured by magnetic resonance imaging.
  • R. Gur, P. Mozley, D. Berretta
  • Medicine, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1991
It is suggested that women are less vulnerable to age-related changes in mental abilities, whereas men are particularly susceptible to aging effects on left hemispheric functions.
The young adult human brain: an MRI-based morphometric analysis.
The results represent the first step in establishing a comprehensive database of morphometric parameters, with unexpected findings relative to brain symmetry and sexual dimorphism.