A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains

  title={A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains},
  author={Catriona D. Good and Ingrid S. Johnsrude and John Ashburner and Richard N. A. Henson and Karl J. Friston and Richard S. Frackowiak},
Voxel-based-morphometry (VBM) is a whole-brain, unbiased technique for characterizing regional cerebral volume and tissue concentration differences in structural magnetic resonance images. We describe an optimized method of VBM to examine the effects of age on grey and white matter and CSF in 465 normal adults. Global grey matter volume decreased linearly with age, with a significantly steeper decline in males. Local areas of accelerated loss were observed bilaterally in the insula, superior… 

Figures and Tables from this paper

Age-related changes in regional brain volume evaluated by atlas-based method
An atlas-based method is introduced as a methodological alternative that calculates absolute volume as a non-biased and semi-automatic whole-brain technique and has an advantage over the VBM method in its computability of absolute volume.
Adjusting for global effects in voxel-based morphometry: Gray matter decline in normal aging
Voxel-based morphometry in Alzheimer’s disease
Findings related to different AD stages and its prodrome, mild cognitive impairment are reviewed, including not only gray matter deficits in medial temporal structures as seen in former MRI studies of AD conducted using manual region-of-interest measurements, but also volume changes in several other brain regions not assessed in previous MRI studies.
Voxel-based morphometry of the human brain: Methods and applications
VBM has been useful in characterizing subtle changes in brain structure in a variety of diseases associated with neurological and psychiatric dysfunction, including schizophrenia, developmental and congenital disorders, temporal lobe epilepsy and even cluster headache.
Brain Structural Variability due to Aging and Gender in Cognitively Healthy Elders: Results from the São Paulo Ageing and Health Study
The detection of age-related limbic GM decrease in men supports the view that atrophy in such regions should be seen as compatible with normal aging, and highlights the complexity of degenerative processes that affect the healthy human brain across the life span.


Sex differences in brain aging: a quantitative magnetic resonance imaging study.
The results are generally consistent with the few published studies on sex differences in brain aging and suggest that, for at least some structures, aging effects may be more apparent in men than women.
Age and Gender Predict Volume Decline in the Anterior and Posterior Hippocampus in Early Adulthood
Results suggest a larger shrinkage for men of brain gray matter, with controversial observations being made for the HC, and underscores the need to include sociodemographic variables in functional and anatomical MRI designs.
Selective aging of the human cerebral cortex observed in vivo: differential vulnerability of the prefrontal gray matter.
Small but consistent rightward asymmetry was found in the whole cerebral hemispheres, superior parietal, fusiform and orbito-frontal cortices, postcentral and prefrontal white matter, and in the parietal white matter.
One-year age changes in MRI brain volumes in older adults.
Definition of the pattern and rate of longitudinal brain changes will facilitate the detection of pathological brain changes, which may be predictors of dementia, in nondemented older participants in the Baltimore Longitudinal Study of Aging.
Pathoclysis in aging human cerebral cortex: Evidence from in vivo MRI morphometry
The results of the reported studies support the notion of selective aging of cortical association areas accompanied by relative sparing of sensory cortices.
Brain gray and white matter volume loss accelerates with aging in chronic alcoholics: a quantitative MRI study.
The increased brain tissue loss with advanced age is interpreted as evidence for age-related increase in brain vulnerability to chronic alcohol abuse.
A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood.
These patterns of growth and change seen in vivo with MRI are largely consistent with neuropathological studies, as well as animal models of development, and may reflect neuronal progressive and regressive processes, including cell growth, myelination, cell death, and atrophy.
The young adult human brain: an MRI-based morphometric analysis.
The results represent the first step in establishing a comprehensive database of morphometric parameters, with unexpected findings relative to brain symmetry and sexual dimorphism.
Differential aging of the human striatum: a prospective MR imaging study.
Bilateral age-related shrinkage of the neostriatum is found in healthy adults and may be restricted to men only, and significant rightward asymmetry in the putamen, significant leftward asymmetric in the caudate, and no asymmetryIn the globus pallidus is observed.