A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains

@article{Good2001AVM,
  title={A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains},
  author={Catriona D. Good and Ingrid S. Johnsrude and John Ashburner and Richard N. A. Henson and Karl J. Friston and Richard S. Frackowiak},
  journal={NeuroImage},
  year={2001},
  volume={14},
  pages={21-36}
}
Voxel-based-morphometry (VBM) is a whole-brain, unbiased technique for characterizing regional cerebral volume and tissue concentration differences in structural magnetic resonance images. We describe an optimized method of VBM to examine the effects of age on grey and white matter and CSF in 465 normal adults. Global grey matter volume decreased linearly with age, with a significantly steeper decline in males. Local areas of accelerated loss were observed bilaterally in the insula, superior… 
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