A Voltage Sensor-Domain Protein Is a Voltage-Gated Proton Channel

@article{Sasaki2006AVS,
  title={A Voltage Sensor-Domain Protein Is a Voltage-Gated Proton Channel},
  author={Mari Sasaki and Masahiro Takagi and Yasushi Okamura},
  journal={Science},
  year={2006},
  volume={312},
  pages={589 - 592}
}
Voltage-gated proton channels have been widely observed but have not been identified at a molecular level. Here we report that a four-transmembrane protein similar to the voltage-sensor domain of voltage-gated ion channels is a voltage-gated proton channel. Cells overexpressing this protein showed depolarization-induced outward currents accompanied by tail currents. Current reversal occured at equilibrium potentials for protons. The currents exhibited pH-dependent gating and zinc ion… Expand

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